Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis.
Phan Vuong Khac ThaiDang Thi Minh HaNguyen Thi HanhJeremy DaySarah DunstanNguyen Thi Quynh NhuVo Sy KietNguyen Huu LanNguyen Huy DungNguyen Thi Ngoc LanNguyen Thuong ThuongNguyen Ngoc LanPhạm Thị Thúy LiễuNguyễn Thị HồngĐào Công ĐiệpNguyễn Thị Kim ThanhNguyễn Văn HộiNguyễn Văn NghĩaTrương Ngọc ĐạiHoàng Quang MinhNguyễn Văn ThơmJeremy FarrarMaxine CawsPublished in: BMC infectious diseases (2018)
One third of isoniazid resistant TB cases suffered failure/relapse within 2 years under the old eight month regimen. Over half of these cases were not identified by standard WHO recommended treatment monitoring. Intensified research on early identification and optimal regimens for isoniazid resistant TB is needed. Infection with Beijing genotype of TB is a significant risk factor for bacterial persistence on treatment resulting in failure/relapse within 2 years. The underlying mechanism of increased tolerance for standard drug regimens in Beijing genotype strains remains unknown.