Small Molecule Inhibitors of Nuclear Export and the Amelioration of Lupus by Modulation of Plasma Cell Generation and Survival.

Javier Rangel-Moreno Maria De La Luz Garcia-HernandezTeresa OwenJennifer BarnardEnrique Becerril-VillanuevaTrinayan KashyapChristian ArguetaArmando Gamboa-DominguezSharon TamirYosef LandesmanBruce I GoldmanChristopher T RitchlinJennifer H Anolik

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Collectively, our results provide support for the therapeutic potential of SINE compounds, via their targeting of several molecular and cellular pathways critical in lupus pathogenesis, including autoantibody production by plasma cells.

Keyphrases

small molecule
systemic lupus erythematosus
disease activity
induced apoptosis
cell cycle arrest
cell therapy
protein protein
stem cells
endoplasmic reticulum stress
cell death
drug delivery
cell proliferation
bone marrow
pi k akt