Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats.
Bryan S Martinez GalanT D A SerdanL E RodriguesRichelieau ManoelRenata GorjãoLaureane Nunes MasiTania C Pithon-CuriRui CuriSandro Massao HirabaraPublished in: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (2022)
There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats.
Keyphrases
- glycemic control
- adipose tissue
- insulin resistance
- type diabetes
- weight loss
- skeletal muscle
- metabolic syndrome
- physical activity
- blood glucose
- high fat diet
- bariatric surgery
- polycystic ovary syndrome
- obese patients
- cardiovascular disease
- high intensity
- high fat diet induced
- body mass index
- mental health
- atrial fibrillation
- left ventricular
- resistance training
- risk factors
- postmenopausal women
- study protocol