Pancreas-directed AAV8 -hSPINK1 gene therapy safely and effectively protects against pancreatitis in mice.

Yuan-Chen WangXiao-Tong MaoChang SunYa-Hui WangYi-Zhou ZhengSi-Huai XiongMu-Yun LiuSheng-Han MaoQi-Wen WangGuo-Xiu MaDi WuZhao-Shen LiJian-Min ChenWen-Bin Zou Zhuan Liao

Published in: Gut (2024)

safely targets the pancreas with high transduction efficiency and effectively ameliorates pancreatitis phenotypes in mice. This approach is promising for the prevention and treatment of CP.

Keyphrases

gene therapy
high fat diet induced
type diabetes