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Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights.

Mohamed Abdelwahab AbdelgawadArafa MusaAtiah H AlmalkiSami I AlzareaEhab M MostafaMostafa M HegazyGomaa Mostafa-HedeabMohammed M GhoneimDella G T ParambiRania B BakrNayef S Al-MuaikelAbdullah Salah AlanaziMetab AlharbiWaqas AhmadSyed Nasir Abbas BukhariMohammad M Al-Sanea
Published in: Drug design, development and therapy (2021)
The NMR of prepared compounds showed characteristic peaks that confirmed the structure of the target compounds. The synthesized benzoxazolyl scaffold containing compounds showed inhibitory activities for both COXs and EGFR which are consistent with the virtual docking study.
Keyphrases
  • small cell lung cancer
  • epidermal growth factor receptor
  • tyrosine kinase
  • magnetic resonance
  • molecular dynamics
  • high resolution
  • molecular dynamics simulations
  • small molecule
  • solid state
  • tissue engineering