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p53 Genetics and Biology in Lung Carcinomas: Insights, Implications and Clinical Applications.

Dixan A BenitezGuadalupe Cumplido-LasoMarcos Olivera-GómezNuria Del Valle-Del PinoAlba Díaz-PizarroSonia Mulero-NavarroAngel Román-GarcíaJose Maria Carvajal-Gonzalez
Published in: Biomedicines (2024)
The TP53 gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often contributes to the initiation and progression of various cancers, including lung cancer (LC) subtypes. The review explores the intricate relationship between p53 and its role in the development and progression of LC. p53, a crucial tumor suppressor protein, exists in various isoforms, and understanding their distinct functions in LC is essential for advancing our knowledge of this deadly disease. This review aims to provide a comprehensive literature overview of p53, its relevance to LC, and potential clinical applications.
Keyphrases
  • cell cycle
  • simultaneous determination
  • cell proliferation
  • mass spectrometry
  • liquid chromatography
  • copy number
  • healthcare
  • oxidative stress
  • genome wide
  • tandem mass spectrometry
  • cell cycle arrest
  • protein protein