Clever-1 positive macrophages in breast cancer.
Minna MutkaReetta VirtakoivuKristiina JoensuuMaija HollménPäivi HeikkiläPublished in: Breast cancer research and treatment (2022)
The association of intratumoral Clever-1 + macrophages with better prognosis might stem from the function of Clever as a scavenger receptor that modulates tumor stroma. The association of Clever-1 + macrophages with high number of TILs and better prognosis indicates that immunosuppression by M2 macrophages is not necessarily dampening adaptive immune responses but instead keeping them in control to avoid excess inflammation.
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