Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles.
Flor SanchezAnh H LeVu N A HoSergio RomeroHeidi Van RanstMichel De VosRobert B GilchristTuong M HoLan N VuongJohan E J SmitzPublished in: Journal of assisted reproduction and genetics (2019)
CAPA-IVM brings significant improvements in maturation and embryological outcomes, most notably to oocytes from small antral follicles (< 6 mm), which can be easily retrieved from patients with a minimal ovarian stimulation. The study demonstrates the robustness and transferability of the CAPA-IVM method across laboratories and populations.