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High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy.

Cynthia ShuLiubov ParfenovaEkaterina MokhonovaJudd R ColladoRobert DamoiseauxJesus CampagnaVarghese JohnRachelle H Crosbie
Published in: Skeletal muscle (2020)
This study identifies a pharmacological approach to treat DMD and sets the path for the development of SSPN-based therapies.
Keyphrases
  • duchenne muscular dystrophy
  • mouse model
  • genome wide
  • induced apoptosis
  • muscular dystrophy
  • cell cycle arrest
  • small molecule
  • skeletal muscle
  • gene expression
  • oxidative stress
  • cell death
  • cell proliferation
  • pi k akt