FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation.

Cheng-Fen TuMeng-Ying WuYuh-Charn LinReiji KannagiRuey-Bing Yang

Published in: Breast cancer research : BCR (2017)

Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-β signaling and EMT, thus stimulating breast cancer cell invasion and metastasis.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
genome wide
binding protein
breast cancer risk