Esophageal mucosal innervation in functional heartburn: Closer to healthy asymptomatic subjects than to non-erosive reflux disease patients.

Kornilia Nikaki Philip WoodlandChung LeeMatteo GhisaCarla MarinelliEdoardo SavarinoDaniel Sifrim

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

The mucosal innervation pattern in FH is more alike that of healthy individuals than that of NERD, with afferent nerves lying deep in the mucosa, away from the luminal surface. This supports the theory that heartburn in FH has a distinct nociceptive pathophysiology.

Keyphrases

end stage renal disease
ejection fraction
peritoneal dialysis
neuropathic pain
patient reported outcomes
spinal cord injury
patient reported
gastroesophageal reflux disease