New Verticillene Diterpenoids, Eudesmane Sesquiterpenoids, and Hydroperoxysteroids from the Further Chemical Investigation of a Taiwanese Soft Coral Cespitularia sp.

An investigation of the chemical composition of a Formosan soft coral Cespitularia sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M ( 1 ); one new eudesmane sesquiterpenoid, cespilamide F ( 2 ); and three new hydroperoxysteroids ( 3 - 5 ) along with twelve known analogous metabolites ( 6 - 17 ). In addition, one new derivative, cespitulactam M-6,2'-diacetate ( 1a ), was prepared from compound 1 . The structures were determined by detailed spectroscopic analyses, particularly HRESIMS and NMR techniques. Moreover, the in vitro cytotoxicity, anti-inflammatory, and antibacterial activity of 1 - 17 and 1a were evaluated.