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Spatial Multiplexed Protein Profiling of Cardiac Ischemia-Reperfusion Injury.

Luyan YaoFunan HeQuanyi ZhaoDandan LiShufang FuMingzhi ZhangXingzhong ZhangBingying ZhouLi Wang
Published in: Circulation research (2023)
We mapped the spatiotemporal heterogeneity of cellular phenotypes in the adult heart upon IRI, and uncovered H3K9me3 in endothelial cells as a potential therapeutic target for alleviating pathological remodeling of the heart following myocardial IRI.
Keyphrases
  • single cell
  • ischemia reperfusion injury
  • endothelial cells
  • left ventricular
  • heart failure
  • atrial fibrillation
  • oxidative stress
  • protein protein
  • human health
  • small molecule