Impact of 12-SNP and 6-SNP Polygenic Scores on Predisposition to High LDL-Cholesterol Levels in Patients with Familial Hypercholesterolemia.

Giovanna CardieroMartina FerrandinoIlenia Lorenza CalcaterraGabriella Iannuzzo Matteo Nicola Dario Di Minno Raffaele Buganza Ornella GuardamagnaRenata AuricchioMaria Donata Di TarantoGiuliana Fortunato

Published in: Genes (2024)

The 12-SNP and 6-SNP polygenic scores could explain hypercholesterolemia in patients without pathogenic variants as well as the variability of LDL-c levels among patients with FH-causative variants.

Keyphrases

genome wide
low density lipoprotein
copy number
high density
end stage renal disease
ejection fraction
dna methylation
newly diagnosed
genetic diversity
prognostic factors
type diabetes
cardiovascular disease