IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.

Josy AugustineSofia PavlouImran AliKevin HarkinEma OzakiMatthew CampbellAlan W StittHeping XuMei Chen

Published in: Journal of neuroinflammation (2019)

IL-33 deficiency enhanced retinal degeneration and gliosis following RD which was related to sustained subretinal inflammation from infiltrating macrophages. IL-33 may provide a previously unrecognised protective response by negatively regulating macrophage activation following retinal detachment.

Keyphrases

oxidative stress
optical coherence tomography
early onset
replacement therapy
smoking cessation