Does the association between adherence to statin medications and mortality depend on measurement approach? A retrospective cohort study.
Mhd Wasem AlsabbaghDean EurichLisa M LixThomas W WilsonDavid F BlackburnPublished in: BMC medical research methodology (2017)
Unlike the summary measure, the repeated measures approach produces a significant reduction of all-cause mortality with optimal adherence. This effect may be a result of the repeated measures approach being more sensitive, or more prone to survival bias. Our findings clearly demonstrate the need to undertake (and report) multiple approaches when assessing the benefits of medication adherence.