Detrimental Role of PDZ-RhoGEF in Pathological Cardiac Hypertrophy.

Jia HuangQingrong QuYuxiang DaiDaoyuan RenJuying Qian Jun-Bo Ge

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Our data provide the first evidence that PDZ-RhoGEF promotes pathological cardiac hypertrophy by linking activated Gα13 to RhoA-dependent signaling pathways. Therefore, PDZ-RhoGEF has the potential to be a diagnostic marker or therapeutic target for pathological cardiac hypertrophy.

Keyphrases

signaling pathway
electronic health record
epithelial mesenchymal transition
machine learning
human health