Atrial fibrillation in Brugada syndrome: Current perspectives.
Konstantinos VlachosGiuseppe MasciaClaire A MartinGeorge BazoukisAntonio FronteraGhassen ChnitiKonstantinos P LetsasMicheal EfremidisStamatis GeorgopoulosCharis GkalapisJosselin DuchateauThomas ParmbrunNicholas DervalMélèze HociniMichel HaissaguerrePierre JaisFrédéric SacherPublished in: Journal of cardiovascular electrophysiology (2020)
The incidence of atrial fibrillation (AF) in Brugada syndrome (BrS) has been reported at between 9% and 53% by different series, but the true prevalence is unknown. However, AF may be the presenting feature in some patients. The underlying mechanisms for AF may be a combination of multiple factors, genetic or acquired, that may impact upon autonomic function, atrial structure, and conduction velocities or other unknown factors. The presence of AF has been associated with a more malignant course, with a greater incidence of syncope and ventricular arrhythmias, thus acting as marker of more advanced disease. Regarding the management of patients with AF, antiarrhythmic drugs effective in preventing malignant arrhythmias in BrS such as quinidine or invasive treatment with pulmonary vein isolation (PVI) may be useful in AF treatment. In this review, we aim to present the current perspectives regarding the genetics, pathophysiology, management, and prognosis of AF in patients with BrS.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- risk factors
- end stage renal disease
- percutaneous coronary intervention
- chronic kidney disease
- case report
- machine learning
- pulmonary embolism
- left ventricular
- congenital heart disease
- heart rate
- blood pressure
- acute coronary syndrome
- mitral valve
- venous thromboembolism