Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch.

Norikazu KiguchiFumihiro SaikaYohji FukazawaShinsuke MatsuzakiShiroh Kishioka

Published in: Neuropsychopharmacology reports (2020)

The GRP-GRPR system might be enhanced in the SDH, and itch-responsive GRPR+ neurons largely contribute to intractable itch in a mouse model of psoriasis.

Keyphrases

spinal cord
atopic dermatitis
mouse model
endoplasmic reticulum stress
rheumatoid arthritis
high glucose
cell surface
diabetic rats
ankylosing spondylitis
disease activity
cancer therapy
spinal cord injury
drug delivery
systemic lupus erythematosus
endothelial cells
binding protein