An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase.
Veronica M PravataMichaela OmelkováMarios P StavridisChelsea M DesbiensHannah M StephenDirk J LefeberJozef GeczMehmet GundogduKatrin ÕunapShelagh JossCharles E SchwartzLance WellsDaan M F van AaltenPublished in: European journal of human genetics : EJHG (2020)
Intellectual disability (ID) is a neurodevelopmental condition that affects ~1% of the world population. In total 5-10% of ID cases are due to variants in genes located on the X chromosome. Recently, variants in OGT have been shown to co-segregate with X-linked intellectual disability (XLID) in multiple families. OGT encodes O-GlcNAc transferase (OGT), an essential enzyme that catalyses O-linked glycosylation with β-N-acetylglucosamine (O-GlcNAc) on serine/threonine residues of thousands of nuclear and cytosolic proteins. In this review, we compile the work from the last few years that clearly delineates a new syndromic form of ID, which we propose to classify as a novel Congenital Disorder of Glycosylation (OGT-CDG). We discuss potential hypotheses for the underpinning molecular mechanism(s) that provide impetus for future research studies geared towards informed interventions.