The effect of epididymosomes on the development of frozen-thawed mouse spermatogonial stem cells after culture in a decellularized testicular scaffold and transplantation into azoospermic mice.
Maryam RahbarReza AsadpourZohreh MazaheriPublished in: Journal of assisted reproduction and genetics (2024)
The DTM hydrogel containing 20 µg/mL epididymosomes or 10 ng/mL GDNF is a novel and safe culture system that can support SSC proliferation in vitro to obtain adequate SSCs for transplantation success. It could be a novel therapeutic agent that could recover deregulated SSCs in azoospermic patients.
Keyphrases
- stem cells
- end stage renal disease
- ejection fraction
- tissue engineering
- cell therapy
- newly diagnosed
- chronic kidney disease
- drug delivery
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- metabolic syndrome
- high fat diet induced
- skeletal muscle
- wound healing
- insulin resistance
- pregnant women
- hyaluronic acid