Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis.

Margaret L DahnHayley R WalshCheryl A DeanMichael A GiacomantonioWasundara FernandoJ Patrick MurphyOlivia L WalkerMarie-Claire D WassonShashi GujarDevanand M PintoPaola Marcato

Published in: Metabolomics : Official journal of the Metabolomic Society (2022)

This study revealed a novel pathway affected by ALDH1A3, GABA metabolism. Like ALDH1A3 expression, GABA treatment promotes metastasis. Given the clinical use of GABA mimics to relieve chemotherapy-induced peripheral nerve pain, further study of the effects of GABA in breast cancer progression is warranted.

Keyphrases

peripheral nerve
single cell
chemotherapy induced
spinal cord
neuropathic pain
breast cancer risk