The impact of calcification patterns in transcatheter aortic valve performance: a fluid-structure interaction analysis.
Giulia LuraghiJose Felix Rodriguez MatasMarta BerettaNicole ChiozziLaura IannettiFrancesco MigliavaccaPublished in: Computer methods in biomechanics and biomedical engineering (2020)
Transcatheter aortic valve replacement (TAVR) strongly depends on the calcification patterns, which may lead to a malapposition of the stented valve and complication onsets in terms of structure kinematics and paravalvular leakage (PVL). From one anatomical-resembling model of the aortic root, six configurations with different calcific deposits were built. TAVR fluid-structure interaction simulations predicted different outcomes for the different calcifications patterns in terms of the final valve configuration in the implantation site and the PVL estimations. In particular models with deposits along the cups coaptation resulted in mild PVL, while those with deposits along the attachment line in moderate PVL.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- chronic kidney disease
- molecular dynamics
- heart failure
- atrial fibrillation
- coronary artery disease
- mitral valve
- adipose tissue
- total hip arthroplasty
- pulmonary artery
- insulin resistance
- pulmonary arterial hypertension