Autophagy modulation effect on homotypic transfer of intracellular components via tunneling nanotubes in mesenchymal stem cells.

Fatemeh SadeghsoltaniÇığır Biray AvciParisa HassanpourSanya HaiatyMohamad RahmatiAli MotaReza RahbarghaziMaryam NematiMahdi MahdipourMehdi TalebiLeila Sabour TakanlouMaryam Sabour TakanlouAmir Mehdizadeh

Published in: Stem cell research & therapy (2024)

In summary, autophagy modulation could affect TNT formation which is required for homotypic mitochondrial donation. Thus, the modulation of autophagy creates a promising perspective to increase the efficiency of cell-based therapies.

Keyphrases

cell death
oxidative stress
endoplasmic reticulum stress
mesenchymal stem cells
signaling pathway
cell therapy
bone marrow
umbilical cord
stem cells
reactive oxygen species