A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh.
Golap BabuShad Bin IslamMd Asaduzzaman KhanPublished in: Molecular biology reports (2022)
Cancer is one of the major health burdens worldwide, and genetic polymorphisms in individuals are closely associated with cancer susceptibility. Like in many other developing countries, the risk of cancer is increasing among Bangladeshi population. Genetic polymorphisms in xenobiotic metabolic enzymes (CYP1A1, CYP2A6, CYP3A4, CYP3A5, NAT2, SULT1A), cell cycle regulatory proteins (TP53, HER2, MDM2, miR-218-2, TGFB), cell signaling protein (CDH1), DNA repair proteins (BRCA1, BRCA2, EXO1, RAD51, XRCC2, ECCR1, ERCC4, XPC, ERCC2), and others (HLA-DRB1, INSIG2, GCNT1P5) have been found to be associated with various cancers like cancers of breast, bladder, cervix, colon, lung, prostate, etc. in different studies with Bangladeshi population. In this review article, we have discussed these gene polymorphisms associated with cancers in the Bangladeshi population, and also made a comparison with other ethnic groups. This will probably be helpful in understanding drug effects, drug resistance, and personalized medicine in the population of this region.
Keyphrases
- dna repair
- cell cycle
- papillary thyroid
- dna damage
- cell proliferation
- squamous cell
- childhood cancer
- prostate cancer
- dna damage response
- healthcare
- public health
- spinal cord injury
- emergency department
- lymph node metastasis
- mental health
- long non coding rna
- stem cells
- squamous cell carcinoma
- social media
- cell therapy
- transcription factor
- mesenchymal stem cells
- health information
- risk assessment
- benign prostatic hyperplasia