Both partial inactivation as well as activation of NF-κB signaling lead to hypertension and chronic kidney disease.
Xiaotan ZhangGuang WangMing LiYunjin LiXin LuoYvonne LiuXiaoli ZhangJohann-Georg HocherBernhard K KrämerBerthold HocherXuesong YangPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)
Using mice models with partially activated and inactivated NF-κB pathways suggests that there is an apparently U-shaped relationship between blood pressure, kidney function as well as morphology and the activation of the NF-κB pathway. A certain optimal activity of the NF-κB pathway seems to be important to maintain optimal kidney function and morphology.