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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy.

Laura N EadieElias LagonikElyse C PageCaitlin E SchutzSusan L HeatleyBarbara J McClureMichelle Olivia ForgioneDavid T O YeungTimothy P HughesDeborah L White
Published in: Blood (2024)
High-risk Ph-like ALL includes genomic rearrangement of the ABL1 and ABL2 genes (collectively ABL-rearranged, ABLr), and novel treatments are required. For the first time, we demonstrate asciminib efficacy in ABLr ALL, but only when the ABL SH3 domain is present.
Keyphrases
  • tyrosine kinase
  • chronic myeloid leukemia
  • genome wide
  • copy number
  • gene expression
  • genome wide identification