Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level.

Hideyuki TakeshimaYukie YodaMika WakabayashiNaoko HattoriSatoshi YamashitaToshikazu Ushijima

Published in: Clinical epigenetics (2020)

Epigenetic reprogramming of specific cancer-related pathways at the single-cell level is likely to underlie the remarkable efficacy of low-dose DNA demethylating therapy.

Keyphrases

low dose
single cell
rna seq
circulating tumor
high dose
single molecule
cell free
dna methylation
gene expression
stem cells