Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-κB pathway in a chronic migraine model.
Songtang SunZhenzhen FanXuejiao LiuLongde WangZhaoming Ge
Published in: The journal of headache and pain (2024)
Our findings suggest that TREM1 regulates microglia and NLRP3 activation via the NF-κB pathway, thereby contributing to central sensitization and implicating its involvement in chronic migraine pathogenesis.