Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence.

Published in: Expert review of neurotherapeutics (2023)

Clinical studies show that the combinations of dextromethorphan with quinidine or bupropion have been effective in decreasing depressive symptomatology in MDD. However, dextromethorphan studies in adults with TRD or with bipolar depression have shown mixed results. The combination of dextromethorphan and bupropion is a well-tolerated, safe, and efficacious treatment option for adults with MDD. Additional studies analyzing the effects of dextromethorphan and bupropion for TRD and bipolar depression are needed.

Keyphrases

bipolar disorder
major depressive disorder
depressive symptoms
sleep quality
physical activity
case control
replacement therapy
smoking cessation