CHDH-PNPLA3 Gene-Gene Interactions Predict Insulin Resistance in Children with Obesity.

Adela Chiriță-Emandi Costela Lăcrimioara ȘerbanCorina PaulNicoleta AndreescuIulian VeleaAlexandra MihailescuVlad Serafim Diana-Andreea Tiugan Paul Tutac Cristian G Zimbru Maria PuiuMihai Dinu Niculescu

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

The interaction between genotypes in CHDH and PNPLA3 genes, modulated by choline and alanine aminotransferase levels, predicted insulin-resistance status in children with obesity. If replicated in larger cohorts, these findings could help identify metabolic risk in children with obesity.

Keyphrases

insulin resistance
metabolic syndrome
high fat diet induced
type diabetes
young adults
weight loss
genome wide
adipose tissue
weight gain
skeletal muscle
high fat diet
genome wide identification
physical activity
breast cancer risk