PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs.

Annette Dorothea RiegSaid SuleimanCarolin AnkerEva VerjansRolf RossaintStefan UhligChristian Martin

Published in: Respiratory research (2018)

PDGF-BB/PDGFR regulates the pulmonary vascular tone by the generation of prostaglandins, the increase of calcium, the activation of MAPK- or PI3K/AKT/mTOR signalling and actin remodelling. More insights in PDGF-BB downstream-signalling may contribute to develop new therapeutics for PH.

Keyphrases

pulmonary hypertension
growth factor
smooth muscle
signaling pathway
vascular smooth muscle cells
oxidative stress
recombinant human
pi k akt
small molecule
cell migration
pulmonary embolism