CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma.

Nitisha ShrivastavaClaudia Gutierrez ChavezDaniel LiVikas MehtaCarlos ThomasCory D FulcherNicole KawachiDanielle M BottalicoMichael B PrystowskyIndranil BasuChandan GuhaThomas J Ow

Published in: Cancers (2023)

Targeting CDK4/6 can lead to improved efficacy when combined with radiation in OCSCC by inducing senescence and inhibiting DNA damage repair.

Keyphrases

dna damage
squamous cell carcinoma
dna repair
cell cycle
oxidative stress
signaling pathway
radiation therapy
cancer therapy
endothelial cells
drug delivery
locally advanced