Pooled analyses of randomized controlled trials on pyrotinib plus capecitabine and a rethink of the first-line options for HER2-positive relapsed or metastatic breast cancer.
Xiuwen GuanZongbi YiBinghe XuPublished in: Cancer innovation (2022)
This pooled analysis explored the possibility and potential of pyrotinib plus capecitabine as a first-line regimen in relapsed or metastatic HER2-positive breast cancer patients who received prior adjuvant or neoadjuvant chemotherapy with trastuzumab and discussed the potential treatment options for these patients, especially for the patients relapsed during or within 6 months after adjuvant trastuzumab.
Keyphrases
- metastatic breast cancer
- neoadjuvant chemotherapy
- end stage renal disease
- acute lymphoblastic leukemia
- acute myeloid leukemia
- ejection fraction
- locally advanced
- newly diagnosed
- chronic kidney disease
- positive breast cancer
- early stage
- diffuse large b cell lymphoma
- multiple myeloma
- small cell lung cancer
- peritoneal dialysis
- prognostic factors
- hodgkin lymphoma
- lymph node
- epidermal growth factor receptor
- clinical trial
- rectal cancer
- open label