Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells.

Sujoy BhattacharyaJinggang YinWeihong HuoEdward Chaum

Published in: Stem cell research & therapy (2022)

Our studies demonstrate that the MELAS iPSC-derived disease models are powerful tools for dissecting the molecular mechanisms by which mitochondrial DNA alterations influence RPE function in aging and macular degeneration, and for testing novel therapeutics in patients harboring the MELAS genotype.

Keyphrases

mitochondrial dna
end stage renal disease
copy number
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
optical coherence tomography
cell death
peritoneal dialysis
small molecule
endoplasmic reticulum stress
gene expression
patient reported
cataract surgery