Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1.

Emarene KalawMalcolm LimJamie R KutasovicAnna SokolovaLucinda TaegeKate JohnstoneJames BennettJodi M SaunusColleen NilandKaltin FergusonIrma GresshoffMark BettingtonNirmala PathmanathanGary M TseDavid PapadimosRajadurai PathmanathanGavin HarrisRin YamaguchiPuay Hoon TanStephen FoxSandra A O'ToolePeter T SimpsonSunil R LakhaniAmy E McCart Reed

Published in: British journal of cancer (2020)

Our findings indicate the clinical significance and prognostic value of FOXP3, PD-1/PD-L1 checkpoint and TILs in metaplastic breast cancer and confirm that a subset of metaplastics may benefit from immune-based therapies.

Keyphrases

regulatory t cells
dna damage
dendritic cells
cell cycle
immune response
oxidative stress
cell proliferation
young adults
breast cancer risk