Effect of tyrosine kinase inhibitors on cell migration and epithelial-to-mesenchymal transition in Asian head and neck cancer cell lines.

Aye Myat ThwePeter MosseyIan R Ellis

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)

These data suggest that Gefitinib and Erlotinib prevent activation of downstream signalling proteins MAPK (Thr202/Tyr204) and Akt (Ser473) thereby blocking phenotypic change and cell migration. This study supports the potential therapeutic value of Gefitinib and Erlotinib in targeting head and neck cancer.

Keyphrases

cell migration
epidermal growth factor receptor
small cell lung cancer
signaling pathway
advanced non small cell lung cancer
tyrosine kinase
oxidative stress
cell proliferation
electronic health record
cancer therapy
pi k akt
drug delivery
machine learning
artificial intelligence