Transcriptomic analysis of benign prostatic hyperplasia identifies critical pathways in prostatic overgrowth and 5-alpha reductase inhibitor resistance.
Renjie JinConnor M ForbesNicole L MillerJohn T LafinDouglas W StrandThomas CaseJustin Merrill Marken CatesQi LiuMarisol Ramirez-SolanoJames L MohlerRobert J MatusikPublished in: The Prostate (2024)
Reduction analysis of BPH and 3D organoid culture uncovered networks previously identified in prostatic development as being reinitiated in BPH. Identification of these pathways provides insight into the failure of medical therapy for BPH and new therapeutic targets for BPH/LUTS.