A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies.
Lydia L SimpsonCraig 'd SteinbackMichael StembridgeJonathan P MoorePublished in: Experimental physiology (2020)
High altitude (HA) hypoxia is a potent activator of the sympathetic nervous system, eliciting increases in sympathetic vasomotor activity. Microneurographic evidence of HA sympathoexcitation dates back to the late 20th century, yet only recently have the characteristics and underpinning mechanisms been explored in detail. This review summarises recent findings and highlights the importance of HA sympathoexcitation for the regulation of blood pressure in lowlanders and indigenous highlanders. In addition, this review identifies gaps in our knowledge and corresponding avenues for future study.