DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts.

Martina RimoldiNing WangJilin ZhangDiego VillarDuncan T OdomJussi TaipalePaul FlicekMaša Roller

Published in: Genome biology (2024)

Our epigenomic analyses indicate a role for DNA methylation in TF binding changes across species including that specific DNA methylation profiles characterize TF binding and are associated with their regulatory activity, chromatin contexts, and evolutionary trajectories.

Keyphrases

dna methylation
genome wide
transcription factor
dna binding
gene expression
copy number
binding protein
dna damage
depressive symptoms
oxidative stress