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Genetic insight into sick sinus syndrome.

Rosa B ThorolfsdottirGardar SveinbjörnssonHildur M AegisdottirStefania BenonisdottirLilja StefansdottirErna V IvarsdottirGisli Hreinn HalldorssonJon K SigurdssonChristian Torp-PedersenPeter E WeekeSøren BrunakDavid WestergaardOle Birger Vesterager PedersenErik SorensenKaspar René NielsenKristoffer Sølvsten BurgdorfKarina BanasikBen Michael BrumptonWei ZhouAsmundur OddssonVinicius TraganteKristján Eldjárn HjörleifssonOlafur B DavidssonSridharan RajamaniStefan JonssonBjarni TorfasonAtli S ValgardssonGudmundur ThorgeirssonMichael L FriggeGudmar ThorleifssonGudmundur L NorddahlAnna HelgadottirSolveig GretarsdottirPatrick SulemIngileif JónsdóttirCristen J WillerKristian HveemHenning BundgaardHenrik UllumDavid O ArnarUnnur ThorsteinsdottirDaníel F GuðbjartssonHilma HólmKári Stefánssonnull null
Published in: European heart journal (2022)
We report the associations of variants at six loci with SSS, including a missense variant in KRT8 that confers high risk in homozygotes and points to a mechanism specific to SSS development. Mendelian randomization supports a causal role for AF in the development of SSS.
Keyphrases
  • genome wide
  • atrial fibrillation
  • intellectual disability
  • gene expression
  • dna methylation
  • autism spectrum disorder