Genetic insight into sick sinus syndrome.
Rosa B ThorolfsdottirGardar SveinbjörnssonHildur M AegisdottirStefania BenonisdottirLilja StefansdottirErna V IvarsdottirGisli Hreinn HalldorssonJon K SigurdssonChristian Torp-PedersenPeter E WeekeSøren BrunakDavid WestergaardOle Birger Vesterager PedersenErik SorensenKaspar René NielsenKristoffer Sølvsten BurgdorfKarina BanasikBen Michael BrumptonWei ZhouAsmundur OddssonVinicius TraganteKristján Eldjárn HjörleifssonOlafur B DavidssonSridharan RajamaniStefan JonssonBjarni TorfasonAtli S ValgardssonGudmundur ThorgeirssonMichael L FriggeGudmar ThorleifssonGudmundur L NorddahlAnna HelgadottirSolveig GretarsdottirPatrick SulemIngileif JónsdóttirCristen J WillerKristian HveemHenning BundgaardHenrik UllumDavid O ArnarUnnur ThorsteinsdottirDaníel F GuðbjartssonHilma HólmKári Stefánssonnull nullPublished in: European heart journal (2022)
We report the associations of variants at six loci with SSS, including a missense variant in KRT8 that confers high risk in homozygotes and points to a mechanism specific to SSS development. Mendelian randomization supports a causal role for AF in the development of SSS.