Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway.
Yiting ZhangYan DingTai LuYixin ZhangNingbo XuDevin W McBrideJiping TangArne P NeyrinckPublished in: Journal of neuroinflammation (2018)
We revealed a BLVRA-dependent signaling pathway in modulating the splenic inflammation in response to GMH via the eNOS/NO/TLR4 pathway.
Keyphrases
- toll like receptor
- inflammatory response
- signaling pathway
- pi k akt
- nuclear factor
- lipopolysaccharide induced
- lps induced
- endothelial cells
- oxidative stress
- nitric oxide synthase
- epithelial mesenchymal transition
- high glucose
- immune response
- induced apoptosis
- diabetic rats
- single cell
- cell proliferation
- drug induced