Identification of a linear B-cell epitope on the Schistosoma japonicum saposin protein, SjSAP4: Potential as a component of a multi-epitope diagnostic assay.

Yi MuCatherine A GordonRemigio M OlvedaAllen G RossDavid U OlvedaJessica M MarshDonald P McManusPengfei Cai

Published in: PLoS neglected tropical diseases (2022)

In this study, -S163QCSLVGDIFVDKYLD178- was identified as a dominant linear B-cell epitope on SjSAP4. This peptide and the complementary recognition of other B-cell epitopes using sera from different KK-positive individuals can provide the basis of developing a multi-epitope assay for the serological diagnosis of schistosomiasis.

Keyphrases

monoclonal antibody
high throughput
binding protein
protein protein
neural network