Discovery and structural assignment of (S)-sydosine from amphipod-derived Aspergillus sydowii MBC15-11F through HRMS, advanced Mosher and molecular modelling analyses.

Mallique QaderLarry L MweetwaTeppo RämäBathini ThisseraBruce F MilneUsama Ramadan AbdelmohsenRaha OrfaliAhmed TawfikeManal EsheliEmmanuel T OluwabusolaLalith JaysaingheMarcel JasparsMostafa E Rateb

Published in: Journal of applied microbiology (2023)

Fermentation of A. sydowii yielded a new (S)-sydosine and known metabolites as predicted by HRESIMS-aided dereplication. Molecular modelling prediction of the absolute configuration of 1 agreed with advanced Mosher analysis.

Keyphrases

ms ms
single molecule
saccharomyces cerevisiae
simultaneous determination