Synthesis of α-Fluorinated Areneacetates through Photoredox/Copper Dual Catalysis.

The development of mild and practical conditions for the fluoroalkylation of arenes is an ongoing challenge in chemical organic synthesis. Herein, we report a metallaphotoredox method for the preparation of fluoroalkyl arenes based on the synergistic combination of Ir/Cu dual catalysis from boronic acids. The mild conditions allow broad functional group tolerance, including substrates containing aldehydes, free phenols, and N -Boc-protected amines. Mechanistic investigations support a process proceeding via photoredox/copper dual catalysis.