Estimated Prevalence of Cryptococcus Antigenemia (CrAg) among HIV-Infected Adults with Advanced Immunosuppression in Namibia Justifies Routine Screening and Preemptive Treatment.

Souleymane SawadogoBoniface MakumbiAnne PurfieldChristophine NdjaveraGram MutandiAndrew MaherFrancina Kaindjee-TjitukaJonathan E KaplanBenjamin J ParkDavid W Lowrance

Published in: PloS one (2016)

This is the first study to estimate CrAg prevalence among HIV-infected patients in Namibia. CrAg prevalence of ≥3.0% among patients with CD4+<100 cells/μL justifies routine CrAg screening and preemptive treatment among HIV-infected in Namibia in line with WHO recommendations. Patients with CD4+<100 cells/μL have a significantly greater risk for CrAg positivity. Revised guidelines for ART in Namibia now recommend routine screening for CrAg.

Keyphrases

hiv infected
antiretroviral therapy
clinical practice
hiv infected patients
induced apoptosis
risk factors
cell cycle arrest
human immunodeficiency virus
cell death
oxidative stress
cell proliferation
smoking cessation