Investigating the clinical, pathological and molecular profile of oncocytic adrenocortical neoplasms: a case series and literature review.
Eleanor FewingsSerena Khoo Sert KimAlexey LarionovAlison MarkerOlivier GigerAshley ShawGraeme R ClarkVasilis KosmoliaptsisBenjamin G ChallisMarc TischkowitzRuth T CaseyPublished in: Endocrine oncology (Bristol, England) (2021)
In this study, the LWB classification demonstrated sensitivity for the differentiation of benign from malignant OAN. Molecular profiling identified dysregulation in DNA repair and Wnt signalling pathways in both OAN and ACC samples, suggesting a molecular overlap between OAN and conventional ACC.