Insula shows abnormal task-evoked and resting-state activity in first-episode drug-naïve generalized anxiety disorder.

Huiru Cui Bin Zhang Wei Li Hui LiJiaoyan PangQiang HuLanlan ZhangYingying Tang Zhi Yang Jijun Wang Chunbo LiGeorg Northoff

Published in: Depression and anxiety (2020)

Investigating a sample of first-episode, drug-naïve patients, our study demonstrated abnormal interoceptive awareness in patients with GAD and that this was related to abnormal anterior insular activity during both rest and task. These results shed new light on the psychological and neural substrates of somatic symptoms in GAD, and they may serve to establish abnormal interoceptive awareness as a neural and psychological marker of GAD.

Keyphrases

functional connectivity
resting state
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
sleep quality
prognostic factors
peritoneal dialysis
drug induced
emergency department
patient reported outcomes
copy number
dna methylation
depressive symptoms