Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants.

José Tascón-ArcilaSara Rojas-JiménezDiana M Cornejo-SanchezPaola Gómez-BuilesAndrea Ucroz-BenavidesBlear-Maria HolguínDaniel Restrepo-ArbeláezChristhian Gómez-CastilloRodrigo Solarte-MiaWilliam Cornejo-OchoaNicolas Pineda-Trujillo

Published in: Journal of child neurology (2021)

Our rolandic epilepsy cohort presents clinical features clearly different from other cohorts. For instance, age at onset is much earlier in our set of patients, and personal and family history of febrile seizures as well as parasomnias are highly prevalent in our sample. No association of rolandic epilepsy with variants at the 3 genes tested was found. This lack of association may reflect the high genetic heterogeneity of the epilepsies.

Keyphrases

copy number
genome wide
end stage renal disease
chronic kidney disease
ejection fraction
gene expression
prognostic factors
temporal lobe epilepsy
transcription factor
genome wide analysis
chemotherapy induced