Astrocytic transcriptional and epigenetic mechanisms of drug addiction.
Leanne M HoltEric J NestlerPublished in: Journal of neural transmission (Vienna, Austria : 1996) (2023)
Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.