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Astrocytic transcriptional and epigenetic mechanisms of drug addiction.

Leanne M HoltEric J Nestler
Published in: Journal of neural transmission (Vienna, Austria : 1996) (2023)
Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.
Keyphrases
  • gene expression
  • drug induced
  • liver injury
  • dna methylation
  • transcription factor
  • adverse drug
  • mental health
  • white matter
  • oxidative stress
  • resting state
  • multiple sclerosis
  • heat stress
  • electronic health record